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SECISBP2L SECIS binding protein 2 like [ Homo sapiens (human) ]

Gene ID: 9728, updated on 6-Oct-2024

Summary

Official Symbol
SECISBP2Lprovided by HGNC
Official Full Name
SECIS binding protein 2 likeprovided by HGNC
Primary source
HGNC:HGNC:28997
See related
Ensembl:ENSG00000138593 MIM:615756; AllianceGenome:HGNC:28997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLAN; SBP2L
Summary
Enables RNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 34.5), lung (RPKM 24.8) and 25 other tissues See more
Orthologs
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Genomic context

See SECISBP2L in Genome Data Viewer
Location:
15q21.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (48988638..49046446, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (46796860..46854692, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (49280835..49338643, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SHC adaptor protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9380 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49180996-49181177 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:49204976-49206175 Neighboring gene EP300 interacting inhibitor of differentiation 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:49237854-49239053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:49254590-49255092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:49255093-49255594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9381 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49267886-49268121 Neighboring gene keratin 8 pseudogene 24 Neighboring gene MPRA-validated peak2330 silencer Neighboring gene MPRA-validated peak2331 silencer Neighboring gene Sharpr-MPRA regulatory region 10237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9384 Neighboring gene RNA, 7SL, cytoplasmic 577, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:49357796-49358296 Neighboring gene uncharacterized LOC124903489 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:49447830-49448748 Neighboring gene COP9 signalosome subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0256

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
selenocysteine insertion sequence-binding protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193489.2NP_001180418.1  selenocysteine insertion sequence-binding protein 2-like isoform 1

    See identical proteins and their annotated locations for NP_001180418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC008635, BC033001, BM129242, CD678675, D87445
    Consensus CDS
    CCDS53942.1
    UniProtKB/Swiss-Prot
    Q8N767, Q93073
    Related
    ENSP00000453854.1, ENST00000559471.6
    Conserved Domains (1) summary
    pfam01248
    Location:702804
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  2. NM_014701.4NP_055516.2  selenocysteine insertion sequence-binding protein 2-like isoform 2

    See identical proteins and their annotated locations for NP_055516.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the CDS compared to variant 1. The resulting isoform (2) is shorter and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    BM129242, CD678675, D87445, DA394911
    Consensus CDS
    CCDS32234.1
    UniProtKB/Swiss-Prot
    Q93073
    Related
    ENSP00000261847.3, ENST00000261847.7
    Conserved Domains (1) summary
    pfam01248
    Location:657759
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    48988638..49046446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    46796860..46854692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)